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<p>Glucose-6-phosphate dehydrogenase deficiency is prevalent in populations where malaria is endemic. Due to the risk of haemolysis, it is essential to test G6PD before malaria treatment. This study aims to determine the risk of malaria and G6PD deficiency on the occurrence of haemolytic anaemia in children from 6 months to 10 years old, in Douala. A cross-sectional hospital-based study was carried out between February and April 2024. Blood was collected from 143 children at Douala Laquintinie Hospital. A haematological test was done for full blood count. A Biochemical test for G6PD deficiency was done and microscopy for <i>Plasmodium</i> identification was carried out. Data were analysed using Statistical Package for the Social Sciences version 25.0 for data cleaning and analyse with R-studio version 2023.9. A Kruskal-Wallis test was carried out to assess the association between haematological parameters, G6PD levels and malaria. The prevalence of malaria, G6PD deficiency and anaemia among participants were 18.18%, 39.9% and 70.63% respectively. Malaria (<i>p</i> = 0.011) and G6PD deficiency (<i>p</i> = 0.042) were both significantly associated with anaemia. Children with deficient G6PD compared to normal group were statistically associated to a decrease of RBCs (<i>p</i> = 0.034). Of the 26 children with G6PD deficiency, 61.54% (16 children) were found to have anaemia. Malaria-infected children suffering from G6PD deficiency were positively associated to high anaemia. G6PD was statistically associated to a decrease of RBCs. Such data can provide critical clinical guidance to prevent future haemolytic crises in vulnerable paediatric populations. Quantitative enzyme activity testing in females, due to being heterozygous, suspected with milder symptoms is recommended to accurately determine the G6PD status.</p>

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Prevalence of Glucose-6 Phosphate Dehydrogenase Deficiency and Malaria Coinfection and their Association with Anaemia in Children in Douala, Cameroon

  • 期刊论文

  • 发表日期：

    2026年2月2日

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  • Djakissam Watching,
  • Corinne Njeuha Yopa,
  • David Denis Feugaing Sofeu,
  • Elisabeth Menkem Zeuko’o

摘要

Glucose-6-phosphate dehydrogenase deficiency is prevalent in populations where malaria is endemic. Due to the risk of haemolysis, it is essential to test G6PD before malaria treatment. This study aims to determine the risk of malaria and G6PD deficiency on the occurrence of haemolytic anaemia in children from 6 months to 10 years old, in Douala. A cross-sectional hospital-based study was carried out between February and April 2024. Blood was collected from 143 children at Douala Laquintinie Hospital. A haematological test was done for full blood count. A Biochemical test for G6PD deficiency was done and microscopy for Plasmodium identification was carried out. Data were analysed using Statistical Package for the Social Sciences version 25.0 for data cleaning and analyse with R-studio version 2023.9. A Kruskal-Wallis test was carried out to assess the association between haematological parameters, G6PD levels and malaria. The prevalence of malaria, G6PD deficiency and anaemia among participants were 18.18%, 39.9% and 70.63% respectively. Malaria (p = 0.011) and G6PD deficiency (p = 0.042) were both significantly associated with anaemia. Children with deficient G6PD compared to normal group were statistically associated to a decrease of RBCs (p = 0.034). Of the 26 children with G6PD deficiency, 61.54% (16 children) were found to have anaemia. Malaria-infected children suffering from G6PD deficiency were positively associated to high anaemia. G6PD was statistically associated to a decrease of RBCs. Such data can provide critical clinical guidance to prevent future haemolytic crises in vulnerable paediatric populations. Quantitative enzyme activity testing in females, due to being heterozygous, suspected with milder symptoms is recommended to accurately determine the G6PD status.