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<p>Transfusion dependence is a hallmark of myelodysplastic syndromes (MDS) and is increasingly recognized as a prognostic factor. However, data on predictors of transfusion burden and its relationship with survival are limited, especially from resource-constrained settings. We conducted a retrospective cohort study of 86 patients with MDS diagnosed between 2016 and 2020. Baseline demographic, clinical, and hematologic parameters were analyzed. Transfusion burden was quantified as cumulative red blood cell (RBC) units and stratified into three groups: low (&lt; 10 units), moderate (10–20 units), and high (&gt; 20 units). Overall survival (OS) was assessed using Kaplan-Meier analysis. Correlation analysis and linear regression were applied to identify predictors of transfusion density. The cohort included 47 males and 39 females (mean age: 66.1 ± 10.2 years). Females had significantly higher white blood cell (WBC) and platelet counts compared with males (<i>p</i> &lt; 0.05). Median OS declined progressively with transfusion burden: 1240 days (&lt; 10 units), 720 days (10–20 units), and 410 days (&gt; 20 units; log-rank <i>p</i> = 0.003). When assessed continuously, transfusion burden correlated negatively with OS (<i>r</i> = -0.81, <i>p</i> = 0.001). Regression analysis identified baseline hemoglobin (β = -4.97, <i>p</i> = 0.001) and age (β = -0.74, <i>p</i> &lt; 0.0001) as independent predictors of transfusion density. WBC count, platelet count, and marrow blasts were not significant predictors. Transfusion burden is strongly associated with survival in MDS. Baseline hemoglobin and age independently predict transfusion requirements. Quantifying transfusion burden provides clinically relevant prognostic information and should be integrated into routine patient assessment. Myelodysplastic syndrome, Transfusion burden, Overall Survival, Regression analysis, Prognostic factors.</p>

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Predictors of Transfusion Burden and Survival in Patients with Myelodysplastic Syndrome: A Correlation and Regression Analysis

  • 期刊论文

  • 发表日期：

    2026年1月8日

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  • Sourav Chowdhury,
  • Abhishek Das,
  • Anupam Chakrapani,
  • Soumya Bhattacharya,
  • Debmalya Bhattacharyya,
  • Sourav Mukherjee,
  • Sudipta Sekhar Das

摘要

Transfusion dependence is a hallmark of myelodysplastic syndromes (MDS) and is increasingly recognized as a prognostic factor. However, data on predictors of transfusion burden and its relationship with survival are limited, especially from resource-constrained settings. We conducted a retrospective cohort study of 86 patients with MDS diagnosed between 2016 and 2020. Baseline demographic, clinical, and hematologic parameters were analyzed. Transfusion burden was quantified as cumulative red blood cell (RBC) units and stratified into three groups: low (< 10 units), moderate (10–20 units), and high (> 20 units). Overall survival (OS) was assessed using Kaplan-Meier analysis. Correlation analysis and linear regression were applied to identify predictors of transfusion density. The cohort included 47 males and 39 females (mean age: 66.1 ± 10.2 years). Females had significantly higher white blood cell (WBC) and platelet counts compared with males (p < 0.05). Median OS declined progressively with transfusion burden: 1240 days (< 10 units), 720 days (10–20 units), and 410 days (> 20 units; log-rank p = 0.003). When assessed continuously, transfusion burden correlated negatively with OS (r = -0.81, p = 0.001). Regression analysis identified baseline hemoglobin (β = -4.97, p = 0.001) and age (β = -0.74, p < 0.0001) as independent predictors of transfusion density. WBC count, platelet count, and marrow blasts were not significant predictors. Transfusion burden is strongly associated with survival in MDS. Baseline hemoglobin and age independently predict transfusion requirements. Quantifying transfusion burden provides clinically relevant prognostic information and should be integrated into routine patient assessment. Myelodysplastic syndrome, Transfusion burden, Overall Survival, Regression analysis, Prognostic factors.