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<p>The objective of this study is to evaluate the effectiveness of haematological scoring system (HSS) by Rodwell et al. in the early diagnosis of neonatal sepsis, and to correlate the obtained scores with NRBC (nucleated red blood cells) and CRP (C-reactive protein) levels. This study employed a descriptive cross-sectional design. Study considered term neonates within the first 28 days of life and divided into three groups. Group (1): Neonates with sepsis and positive blood culture, Group (2): Neonates with likely infection and but negative blood culture and Group (3): Normal healthy neonates. Groups 1 and 2 included neonates admitted to the NICU (Neonatal Intensive Care Unit). Peripheral blood smears were prepared and stained with Leishman stain. The NRBC count was expressed relative to 100 White Blood Cell (WBC)s. The cut of CRP ≥ 5&#xa0;mg/L was considered as positive. Total leucocytes count reading and Differential counts were conducted by blinded Pathologists, using the HSS criteria by Rodwell et al. The current study showed that the neonates with culture positivity, HSS score of more than 5 showed sensitivity of 85.41% and specificity of 63.29%. The sensitivity of NRBC was found to be 58.33 (%) and specificity 60.75 (%). CRP also showed high sensitivity, specificity, Positive Predictive Value (PPV) and Negative Predictive Value (NPV). Correlation between total HSS Score and NRBC and CRP showed a positive significant correlation. The feasibility and cost-effectiveness of the system make this HSS useful aid in diagnosis of neonatal sepsis and promotes rational patient medication.</p>

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Study of Hematological Scoring System in Neonatal Sepsis and its Correlation with NRBC and CRP at Tertiary Care Hospital from Jharkhand

  • 期刊论文

  • 发表日期：

    2026年1月7日

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  • Jyoti Kumar,
  • Manoj Kumar Paswan,
  • Sunil Kumar Mahto,
  • Kiran Shankar Das,
  • Minal Kumari

摘要

The objective of this study is to evaluate the effectiveness of haematological scoring system (HSS) by Rodwell et al. in the early diagnosis of neonatal sepsis, and to correlate the obtained scores with NRBC (nucleated red blood cells) and CRP (C-reactive protein) levels. This study employed a descriptive cross-sectional design. Study considered term neonates within the first 28 days of life and divided into three groups. Group (1): Neonates with sepsis and positive blood culture, Group (2): Neonates with likely infection and but negative blood culture and Group (3): Normal healthy neonates. Groups 1 and 2 included neonates admitted to the NICU (Neonatal Intensive Care Unit). Peripheral blood smears were prepared and stained with Leishman stain. The NRBC count was expressed relative to 100 White Blood Cell (WBC)s. The cut of CRP ≥ 5 mg/L was considered as positive. Total leucocytes count reading and Differential counts were conducted by blinded Pathologists, using the HSS criteria by Rodwell et al. The current study showed that the neonates with culture positivity, HSS score of more than 5 showed sensitivity of 85.41% and specificity of 63.29%. The sensitivity of NRBC was found to be 58.33 (%) and specificity 60.75 (%). CRP also showed high sensitivity, specificity, Positive Predictive Value (PPV) and Negative Predictive Value (NPV). Correlation between total HSS Score and NRBC and CRP showed a positive significant correlation. The feasibility and cost-effectiveness of the system make this HSS useful aid in diagnosis of neonatal sepsis and promotes rational patient medication.