Scholarlink

<p>Angioimmunoblastic T-cell lymphoma (AITL) is a rare mature T-cell neoplasm with diverse clinical presentations and frequent bone marrow (BM) involvement. Its diagnosis can often be challenging due to atypical features, both in the clinical presentation as well as laboratory findings. We retrospectively analyzed 30 AITL cases that underwent bone marrow examination at our centre between 2017 and 2024. Clinical, laboratory, and flow cytometry (FCM) findings were compared between cases with and without BM involvement. BM involvement was observed in 63.3% of the cases, and correlated with lower hemoglobin level and positivity for direct Coombs test. Unusual presentations included isolated hypereosinophilia, pure red cell aplasia, plasmacytosis, paraneoplastic cranial nerve palsy, and initial misdiagnosis as Hodgkin lymphoma. FCM showed consistent CD4+/CD8− phenotype, frequent CD3 and CD7 downregulation, and expression of two markers related to T follicular helper cell (TFH) phenotype (CD10 and PD-1). AITL may present with clinical and laboratory findings mimicking other neoplastic as well as non-neoplastic diseases. Recognizing unusual presentations is critical for AITL diagnosis. Flow cytometric immunophenotyping aids in early and accurate detection.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Clinico-pathological Findings and Diagnostic Challenges in Angioimmunoblastic T Cell Lymphoma

  • 期刊论文

  • 发表日期：

    2025年12月5日

查看全文
  • Tharageswari Srinivasan,
  • Veeksha Venugopal,
  • Debadrita Ray,
  • Manaswinee Mallik,
  • Nabhajit Mallik,
  • Charanpreet Singh,
  • Praveen Sharma,
  • Amanjit Bal,
  • Sreejesh Sreedharanunni,
  • Man Updesh Singh Sachdeva,
  • Pankaj Malhotra

摘要

Angioimmunoblastic T-cell lymphoma (AITL) is a rare mature T-cell neoplasm with diverse clinical presentations and frequent bone marrow (BM) involvement. Its diagnosis can often be challenging due to atypical features, both in the clinical presentation as well as laboratory findings. We retrospectively analyzed 30 AITL cases that underwent bone marrow examination at our centre between 2017 and 2024. Clinical, laboratory, and flow cytometry (FCM) findings were compared between cases with and without BM involvement. BM involvement was observed in 63.3% of the cases, and correlated with lower hemoglobin level and positivity for direct Coombs test. Unusual presentations included isolated hypereosinophilia, pure red cell aplasia, plasmacytosis, paraneoplastic cranial nerve palsy, and initial misdiagnosis as Hodgkin lymphoma. FCM showed consistent CD4+/CD8− phenotype, frequent CD3 and CD7 downregulation, and expression of two markers related to T follicular helper cell (TFH) phenotype (CD10 and PD-1). AITL may present with clinical and laboratory findings mimicking other neoplastic as well as non-neoplastic diseases. Recognizing unusual presentations is critical for AITL diagnosis. Flow cytometric immunophenotyping aids in early and accurate detection.