Scholarlink

<p>Circulating cell-free DNA (ccf-DNA) and circulating tumor DNA (ctDNA) provide a minimally invasive method for cancer detection and measurement. However, their diagnostic and prognostic significance in hematological malignancies remains ambiguous. This meta-analysis aims to evaluate the prognostic value of ccf-DNA or ctDNA in patients with diffuse large B-cell lymphoma (DLBCL). All relevant literature was retrieved through a systematic search of electronic databases, including PubMed, Embase, Scopus, and the Cochrane Library. Eight eligible studies were selected for the analysis of prognostic value of ccf-DNA or ctDNA. Statistical analyses were performed using R software. The results indicate significant associations with both PFS (HR = 2.14; 95% CI: 1.31–3.40; <i>p</i> &lt; 0.01) and OS (HR = 2.51; 95% CI: 1.84–3.40) for patients with elevated ccf-DNA or ctDNA levels. The results of this meta-analysis strongly suggest that elevated levels of ccfDNA or ctDNA are indicative of poor prognosis in patients with DLBCL.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Prognostic Value of Circulating Tumor DNA (ctDNA) in Diffuse Large B-Cell Lymphoma (DLBCL): Systematic Review and Meta-Analysis

  • 期刊论文

  • 发表日期：

    2025年11月26日

查看全文
  • Anu Kumari,
  • Anupriya Kaur,
  • Charanpreet Singh,
  • Anju Goyal,
  • Arihant Jain,
  • Aditya Jandial,
  • Priyanka Srivastava,
  • Sreejesh Sreedharanunni,
  • Amanjit Bal,
  • Alka Rani Khadwal,
  • Pankaj Malhotra,
  • Gaurav Prakash

摘要

Circulating cell-free DNA (ccf-DNA) and circulating tumor DNA (ctDNA) provide a minimally invasive method for cancer detection and measurement. However, their diagnostic and prognostic significance in hematological malignancies remains ambiguous. This meta-analysis aims to evaluate the prognostic value of ccf-DNA or ctDNA in patients with diffuse large B-cell lymphoma (DLBCL). All relevant literature was retrieved through a systematic search of electronic databases, including PubMed, Embase, Scopus, and the Cochrane Library. Eight eligible studies were selected for the analysis of prognostic value of ccf-DNA or ctDNA. Statistical analyses were performed using R software. The results indicate significant associations with both PFS (HR = 2.14; 95% CI: 1.31–3.40; p < 0.01) and OS (HR = 2.51; 95% CI: 1.84–3.40) for patients with elevated ccf-DNA or ctDNA levels. The results of this meta-analysis strongly suggest that elevated levels of ccfDNA or ctDNA are indicative of poor prognosis in patients with DLBCL.