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Background <p>Breast cancer (BC) is a complex genetic disorder and a major global health concern among women. The rising incidence of BC highlights the need for reliable molecular biomarkers to enable early diagnosis, monitor disease progression, and guide therapeutic interventions. MicroRNAs (miRNAs) have emerged as promising candidates due to their key regulatory roles in gene expression and their diagnostic and prognostic potential.</p> Methods <p>In this study, serum miR-9-5p expression was evaluated in 100 BC patients and 100 healthy controls using quantitative real-time PCR (qPCR). Potential target genes of hsa-miR-9-5p were predicted using the miRDB database and ranked according to interaction scores.</p> Results <p>Serum miR-9-5p was significantly upregulated in BC patients compared with healthy controls (<i>P-value</i> &lt; 0.0001).</p> Conclusion <p>The marked elevation of serum miR-9-5p in BC patients suggests its possibility potential as a non-invasive biomarker for early detection. The predicted target genes warrant further functional validation to clarify the molecular mechanisms underlying hsa-miR-9-5p–mediated regulation in breast cancer. Independent cohort studies are recommended to confirm these findings and further explore their clinical utility.</p> Graphical abstract <p></p>

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Evaluation of serum microRNA-9-5p expression and its predicted target genes as potential biomarkers for breast cancer

  • 期刊论文

  • 发表日期：

    2026年5月29日

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  • Mahsa Najari Nabi,
  • Omid Asgari Oskoei,
  • Dena Mohammad Bagheri Parvin,
  • Mohammad Taghizadeh-Teymorloei,
  • Mehdi Haghi

摘要

Background

Breast cancer (BC) is a complex genetic disorder and a major global health concern among women. The rising incidence of BC highlights the need for reliable molecular biomarkers to enable early diagnosis, monitor disease progression, and guide therapeutic interventions. MicroRNAs (miRNAs) have emerged as promising candidates due to their key regulatory roles in gene expression and their diagnostic and prognostic potential.

Methods

In this study, serum miR-9-5p expression was evaluated in 100 BC patients and 100 healthy controls using quantitative real-time PCR (qPCR). Potential target genes of hsa-miR-9-5p were predicted using the miRDB database and ranked according to interaction scores.

Results

Serum miR-9-5p was significantly upregulated in BC patients compared with healthy controls (P-value < 0.0001).

Conclusion

The marked elevation of serum miR-9-5p in BC patients suggests its possibility potential as a non-invasive biomarker for early detection. The predicted target genes warrant further functional validation to clarify the molecular mechanisms underlying hsa-miR-9-5p–mediated regulation in breast cancer. Independent cohort studies are recommended to confirm these findings and further explore their clinical utility.

Graphical abstract