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<p>Lymphangioleiomyomatosis (LAM) is a rare, low-grade metastatic disease characterized by cystic lung destruction. The existence of increased breast cancer risk among LAM patients, together with the proposed role of estrogen in the onset and progression of LAM, suggests a potential shared pathophysiological mechanism between LAM and breast cancer. We experienced three cases of early-stage breast cancer with LAM. All three cases were treated with breast-conserving surgery followed by radiation therapy and hormone therapy. There were no serious adverse events associated with the radiotherapy, and the patients have progressed without recurrence or metastasis of breast cancer or worsening of LAM in any of the values measured during the follow-up period.</p>

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Three cases of whole breast irradiation for breast cancer in patients with Lymphangioleiomyomatosis (LAM)

  • 期刊论文

  • 发表日期：

    2026年3月3日

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  • Rumiko Kinoshita,
  • Mitsuchika Hosoda,
  • Fumi Kato,
  • Hirokazu Kimura,
  • Kaoruko Shimizu,
  • Takashi Mori,
  • Kentaro Nishioka,
  • Takayuki Hashimoto,
  • Masato Takahashi,
  • Satoshi Konno,
  • Hidefumi Aoyama

摘要

Lymphangioleiomyomatosis (LAM) is a rare, low-grade metastatic disease characterized by cystic lung destruction. The existence of increased breast cancer risk among LAM patients, together with the proposed role of estrogen in the onset and progression of LAM, suggests a potential shared pathophysiological mechanism between LAM and breast cancer. We experienced three cases of early-stage breast cancer with LAM. All three cases were treated with breast-conserving surgery followed by radiation therapy and hormone therapy. There were no serious adverse events associated with the radiotherapy, and the patients have progressed without recurrence or metastasis of breast cancer or worsening of LAM in any of the values measured during the follow-up period.