Scholarlink

Objective <p>This randomized-controlled trial aimed to investigate whether preheating thermoplastic elastomer (TPE) bolus to 37&#xa0;°C reduces setup errors and improves patient comfort during post-mastectomy radiotherapy (PMRT).</p> Methods <p>From July 2023 to June 2024, breast cancer patients requiring PMRT were randomized (1:1) to receive either preheated (37&#xa0;°C, 30&#xa0;min) or room-temperature TPE bolus. Bolus was applied during the first half of treatment (15/25 or 8/15 fractions). Weekly cone-beam computed tomography (CBCT) assessed setup errors (lateral [Lat], longitudinal [Lng], vertical [Vrt], and rotational [Rtn]). Secondary endpoints included thorax anteroposterior diameter changes (ΔZ), skin toxicity (CTCAE v3.0), and comfort (modified Likert scale).</p> Results <p>Among 154 analyzed patients, preheating significantly reduced Vrt (0.24 ± 2.43&#xa0;mm vs. − 0.64 ± 2.46&#xa0;mm, <i>p</i> &lt; 0.01) and Lat errors (− 0.12 ± 2.49&#xa0;mm vs. 0.63 ± 2.49&#xa0;mm, <i>p</i> &lt; 0.01). The preheating group reported higher temperature comfort scores (4.32 ± 0.55 vs. 3.59 ± 0.72, <i>p</i> &lt; 0.01). No significant differences were observed in Grade 2 (46.6% vs. 44.3%, <i>p</i> = 0.661) or Grade 3 (2.7% vs. 2.9%, <i>p</i> = 1.000) radiation dermatitis.</p> Conclusion <p>Preheated TPE bolus improves setup accuracy in the Vrt and Lat directions, enhances patient comfort, and maintains skin safety, supporting its clinical utility in PMRT.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Prospective randomized-controlled trial: efficacy of 37 °C-preheated thermoplastic elastomer (TPE) bolus in postoperative radiotherapy for breast cancer patients

  • 期刊论文

  • 发表日期：

    2025年8月20日

查看全文
  • Lihua Zhang,
  • Bo Li,
  • Rong Wang,
  • Jie Li,
  • Rong Cai,
  • Fengbin Zhang,
  • Fating Yang,
  • Zixuan Liu,
  • Lin Yang,
  • Juan Ma,
  • Xiaowei Yao,
  • Qiuxia Hu,
  • Linlin Xu,
  • Jian Zang,
  • Fei Bai,
  • Lina Zhao

摘要

Objective

This randomized-controlled trial aimed to investigate whether preheating thermoplastic elastomer (TPE) bolus to 37 °C reduces setup errors and improves patient comfort during post-mastectomy radiotherapy (PMRT).

Methods

From July 2023 to June 2024, breast cancer patients requiring PMRT were randomized (1:1) to receive either preheated (37 °C, 30 min) or room-temperature TPE bolus. Bolus was applied during the first half of treatment (15/25 or 8/15 fractions). Weekly cone-beam computed tomography (CBCT) assessed setup errors (lateral [Lat], longitudinal [Lng], vertical [Vrt], and rotational [Rtn]). Secondary endpoints included thorax anteroposterior diameter changes (ΔZ), skin toxicity (CTCAE v3.0), and comfort (modified Likert scale).

Results

Among 154 analyzed patients, preheating significantly reduced Vrt (0.24 ± 2.43 mm vs. − 0.64 ± 2.46 mm, p < 0.01) and Lat errors (− 0.12 ± 2.49 mm vs. 0.63 ± 2.49 mm, p < 0.01). The preheating group reported higher temperature comfort scores (4.32 ± 0.55 vs. 3.59 ± 0.72, p < 0.01). No significant differences were observed in Grade 2 (46.6% vs. 44.3%, p = 0.661) or Grade 3 (2.7% vs. 2.9%, p = 1.000) radiation dermatitis.

Conclusion

Preheated TPE bolus improves setup accuracy in the Vrt and Lat directions, enhances patient comfort, and maintains skin safety, supporting its clinical utility in PMRT.