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Background <p>There is no consensus regarding the optimal margin status among patients with breast cancer treated with neoadjuvant chemotherapy (NAC), breast-conserving surgery, and radiotherapy (breast-conserving treatment [BCT]).</p> Methods <p>In total, 1813 patients with newly diagnosed stage 1–3 breast cancer who underwent BCT after NAC were evaluated to determine the impact of margin status on ipsilateral breast tumor recurrence (IBTR).</p> Results <p>During a median follow-up period of 8.0&#xa0;years (range 0.1–17.0&#xa0;years), the 8-year IBTR-free survival rate was 95.9%. Patients with positive margins had significantly worse IBTR-free survival than those with negative margins (8-year IBTR-free survival rate: 87.6% vs. 96.2%, p = 0.010). Multivariate analysis showed that margin status was significantly associated with IBTR-free survival (hazard ratio: 3.1; 95% confidence interval 1.3–7.2; p = 0.0081).</p> Conclusions <p>This multicenter retrospective study demonstrated that margin status is significantly associated with IBTR-free survival in patients who received NAC and BCT, consistent with findings in upfront-surgery cases.</p>

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Impact of margin status on ipsilateral breast tumor recurrence after breast-conserving treatment for patients with breast cancer who received neoadjuvant chemotherapy: a retrospective multi-institutional study of 1813 cases

  • 期刊论文

  • 发表日期：

    2025年6月9日

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  • Makoto Ishitobi,
  • Atsushi Yoshida,
  • Yuri Kimura,
  • Yasuaki Sagara,
  • Yuka Ono,
  • Koji Takada,
  • Yuko Takahashi,
  • Takahiro Tsukioki,
  • Mao Kimoto,
  • Tomo Osako,
  • Takehiko Sakai

摘要

Background

There is no consensus regarding the optimal margin status among patients with breast cancer treated with neoadjuvant chemotherapy (NAC), breast-conserving surgery, and radiotherapy (breast-conserving treatment [BCT]).

Methods

In total, 1813 patients with newly diagnosed stage 1–3 breast cancer who underwent BCT after NAC were evaluated to determine the impact of margin status on ipsilateral breast tumor recurrence (IBTR).

Results

During a median follow-up period of 8.0 years (range 0.1–17.0 years), the 8-year IBTR-free survival rate was 95.9%. Patients with positive margins had significantly worse IBTR-free survival than those with negative margins (8-year IBTR-free survival rate: 87.6% vs. 96.2%, p = 0.010). Multivariate analysis showed that margin status was significantly associated with IBTR-free survival (hazard ratio: 3.1; 95% confidence interval 1.3–7.2; p = 0.0081).

Conclusions

This multicenter retrospective study demonstrated that margin status is significantly associated with IBTR-free survival in patients who received NAC and BCT, consistent with findings in upfront-surgery cases.