Utility of a breast biopsy clip and a point marker system in tailored axillary surgery for patients with breast cancer after neoadjuvant chemotherapy

期刊论文
发表日期：

2024年9月23日

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Yuka Endo,
Haruru Kotani,
Nobuko Tamura,
Kiyo Tanaka,
Chiho Kudo,
Masataka Sawaki,
Masaya Hattori,
Akiyo Yoshimura,
Ayumi Kataoka,
Kazuki Nozawa,
Yuri Ozaki,
Ayaka Isogai,
Rie Komaki,
Akira Nakakami,
Nari Kureyama,
Maho Kusudo,
Waki Hosoda,
Hidetaka Kawabata,
Hiroji Iwata

摘要

Background

Tailored axillary surgery (TAS) is a new approach for selective removal of metastatic lymph nodes. This study evaluated the safety and utility of TAS using a breast biopsy clip inserted into a metastatic lymph node and a point marker consisting of a short hook wire and nylon thread to remove the clipped lymph node.

Methods

Patients with breast cancer and clinically confirmed metastases to one-to-three axillary lymph nodes were included in this study. A breast biopsy clip was inserted into the metastatic lymph nodes before neoadjuvant chemotherapy. TAS was performed in patients with ycN0 disease after neoadjuvant chemotherapy. The lymph nodes containing the clips were removed using a point marker. The success criteria for TAS were the removal of the lymph node into which the clip was inserted using a point marker and the identification of the sentinel lymph node. The false-negative rate was calculated for cases in which TAS and axillary lymph node dissection were performed.

Results

Thirty individuals from two institutions were enrolled between May 2021 and November 2022, of whom 20 underwent TAS. Ten patients had clinically positive axillary lymph nodes and underwent axillary lymph node dissection. No adverse events were observed in any patient using the clips or point markers. TAS was successful in 18 of the 20 patients (90%). Seven patients underwent TAS and axillary lymph node dissection with a false-negative rate of 0%.

Conclusion

The use of clips and point markers to perform TAS is clinically feasible.