The effect of exercise and educational programs for breast cancer patients on the development of breast cancer-related lymphoedema: secondary endpoint from a randomized controlled trial in the Setouchi Breast Project-10

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发表日期：

2024年7月9日

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Shogo Nakamoto,
Takayuki Iwamoto,
Naruto Taira,
Yukiko Kajiwara,
Kengo Kawada,
Daisuke Takabatake,
Yuichiro Miyoshi,
Shinichiro Kubo,
Yoko Suzuki,
Mari Yamamoto,
Yutaka Ogasawara,
Minami Hatono,
Seiji Yoshitomi,
Kyoko Hara,
Asako Sasahara,
Shozo Ohsumi,
Masahiko Ikeda,
Hiroyoshi Doihara,
Yuri Mizota,
Seiichiro Yamamoto,
Tadahiko Shien,
Shinichi Toyooka

摘要

Background

Although the association between higher physical activity and preventive effect on breast-cancer-related lymphoedema (BCRL) has been reported, it is unclear what intervention is optimal. We aimed to investigate the effect of exercise and educational programs on BCRL development.

Methods

This study was a secondary endpoint analysis from a prospective randomized controlled trial. We enrolled patients with stage 0–III breast cancer from March 2016 to March 2020 and randomly assigned them to the control (n = 111), education (n = 115), or exercise (n = 104) group. As secondary endpoint, we assessed the incidence of and preventive effect on BCRL at 12 months post-intervention.

Results

There were no significant differences in the incidence of BCRL at 12 months post-intervention between the exercise and control groups (9.8% and 10.8%, P = 0.83) and the education and control groups (11.6% and 10.8%, P = 1.00). There were no significant differences in time to BCRL onset from the day of surgery between the exercise and control groups (event rate at 12 months: 20.7% and 17.2%, log-rank, P = 0.54) and the education and control groups (18.8% and 17.2%, log-rank, P = 0.57). The multivariable analyses indicated that axillary dissection and obesity significantly increased the risk of BCRL [hazard ratio (HR): 2.36, 95% confidence interval (CI) 1.52–3.67 and HR: 1.68, 95% CI 1.07–2.63, respectively].

Conclusions

The intervention did not decrease the risk of BCRL, and axillary dissection and obesity were the risk factors of BCRL.

Trial registration number

UMIN000020595 at UMIN Clinical Trial Registry.