Purpose of Review <p>To examine current evidence regarding the bidirectional communication within the gut–brain–skin axis, the impact of microbiome dysbiosis on immune regulation, and its contribution to the development of inflammatory dermatoses, particularly those linked to <i>Malassezia</i> species.</p> Recent Findings <p>Emerging research supports a dynamic interaction between the intestinal and cutaneous microbiome, demonstrating that alterations in gut microbial composition can influence systemic immune responses and skin inflammation. Dysbiosis has been associated with increased intestinal permeability, systemic inflammatory signaling, and exacerbation of dermatologic conditions such as acne, psoriasis, atopic dermatitis, alopecia areata, and <i>Malassezia</i>-associated disorders. Additionally, psychosocial stress and dietary factors have been shown to modulate this axis.</p> Summary <p>The gut–brain–skin axis represents a complex regulatory network in which microbial homeostasis plays a central role in maintaining immune balance and skin health. Disruption of this equilibrium may contribute to inflammatory and Malassezia-associated skin diseases. A deeper understanding of these interactions may open new avenues for microbiome-targeted therapeutic strategies.</p>