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<p>Chromanes and chromenes with various biological activities are widespread in nature and have now been found in a variety of plants, fungi and marine organisms. To date, 79 previously undescribed chromanes and 161 previously undescribed chromenes have been isolated and identified. The chromanes were further classified into four skeleton types, and the chromenes were further classified into five skeleton types. In this review, natural chromanes and chromenes were classified according to their skeleton types, and their biological activities and biosynthetic pathways were also summarized. Pharmacological research has demonstrated that chromanes and chromenes possess a range of biological activities, including antimicrobial, anti-inflammatory, anticancer, antidiabetic, and insecticidal properties. This review provides an important reference for structural analysis, pharmacological activity studies, and biosynthetic pathways of chromanes and chromenes.</p>

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Structure, biological activity, and biosynthesis of natural chromanes and chromenes

  • 期刊论文

  • 发表日期：

    2025年11月4日

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  • Ying Liu,
  • Yang Xu,
  • Na Zhang,
  • Hua Li,
  • Lixia Chen

摘要

Chromanes and chromenes with various biological activities are widespread in nature and have now been found in a variety of plants, fungi and marine organisms. To date, 79 previously undescribed chromanes and 161 previously undescribed chromenes have been isolated and identified. The chromanes were further classified into four skeleton types, and the chromenes were further classified into five skeleton types. In this review, natural chromanes and chromenes were classified according to their skeleton types, and their biological activities and biosynthetic pathways were also summarized. Pharmacological research has demonstrated that chromanes and chromenes possess a range of biological activities, including antimicrobial, anti-inflammatory, anticancer, antidiabetic, and insecticidal properties. This review provides an important reference for structural analysis, pharmacological activity studies, and biosynthetic pathways of chromanes and chromenes.