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<p>We present a novel Alveoli-on-Chip (AOC) platform that combines patient-derived organoids with organ-on-chip technology. Primary human lung cells isolated from surgical resections are expanded as organoids – creating a renewable, well-characterized cell bank – then seeded onto the AOC for physiologically relevant 3D cyclic stretch. The new alveoli array on chip mimics the gradient of mechanical stress that lung alveolar epithelial cells are exposed to. RNA sequencing revealed that mechanical stretch upregulated differentiation-associated pathways and attenuated inflammatory signaling, underscoring the platform’s potential for personalized lung research.</p>

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Alveolen-on-Chip: Organoide treffen Organ-on-Chip

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月18日

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  • Jan Schulte,
  • Mohammad Amin Hajari,
  • Thomas Michael Marti,
  • Patrick Dorn,
  • Olivier T. Guenat

摘要

We present a novel Alveoli-on-Chip (AOC) platform that combines patient-derived organoids with organ-on-chip technology. Primary human lung cells isolated from surgical resections are expanded as organoids – creating a renewable, well-characterized cell bank – then seeded onto the AOC for physiologically relevant 3D cyclic stretch. The new alveoli array on chip mimics the gradient of mechanical stress that lung alveolar epithelial cells are exposed to. RNA sequencing revealed that mechanical stretch upregulated differentiation-associated pathways and attenuated inflammatory signaling, underscoring the platform’s potential for personalized lung research.