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<p>Coenzyme Q is a lipid first isolated from mitochondrial membranes in 1957. Despite seven decades of extensive study into its role in the electron transport chain, we are still uncovering the mechanisms that govern its transport from mitochondria, intracellular distribution, and functions beyond respiration. Here, we give a brief overview on recent findings on CoQ biology, focusing on its distribution and its role in ferroptotic cell death.</p>

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Coenzyme Q: the lipophilic shield against ferroptosis

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年6月18日

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  • Sharanya Bhattacharya,
  • Meric Dag,
  • Soni Deshwal

摘要

Coenzyme Q is a lipid first isolated from mitochondrial membranes in 1957. Despite seven decades of extensive study into its role in the electron transport chain, we are still uncovering the mechanisms that govern its transport from mitochondria, intracellular distribution, and functions beyond respiration. Here, we give a brief overview on recent findings on CoQ biology, focusing on its distribution and its role in ferroptotic cell death.