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<p>Selective autophagy requires precise spatial organization to recognize and degrade cellular cargo. We recently found that low-affinity cargo-receptor interactions preserve receptor mobility, enabling formation of initiation hubs, phase-separated assemblies that drive autophagosome biogenesis. These findings suggest autophagy is not only a linear pathway but also guided by physical principles such as wetting, phase separation and multivalency, which are evolutionary conserved and offer therapeutic potential.</p>

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Phasentrennung als Schalter der selektiven Autophagie

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年6月18日

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  • Joachim Brenneisen,
  • Mariya Licheva,
  • Riccardo Babic,
  • Jeremy Pflaum,
  • Hector Mancilla,
  • Florian Wilfling,
  • Claudine Kraft

摘要

Selective autophagy requires precise spatial organization to recognize and degrade cellular cargo. We recently found that low-affinity cargo-receptor interactions preserve receptor mobility, enabling formation of initiation hubs, phase-separated assemblies that drive autophagosome biogenesis. These findings suggest autophagy is not only a linear pathway but also guided by physical principles such as wetting, phase separation and multivalency, which are evolutionary conserved and offer therapeutic potential.