Scholarlink

<p>Cellular antioxidant systems dynamically regulate biological activity, yet their function is typically inferred from static measures. We develop chemical tools that dynamically report on Trx and GSH system activity in living cells. Multicolour activity probe panels can resolve context-dependent differences in redox activity as ratiometric “redox rainbow” signatures. Adapted probes can release therapeutics instead of reporters to selectively address redox-dysregulated tissues with redox prodrugs.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Zelluläre Redoxnetzwerke als funktionelle Reporter biologischer Aktivität

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年5月16日

查看全文
  • Julia Thorn-Seshold

摘要

Cellular antioxidant systems dynamically regulate biological activity, yet their function is typically inferred from static measures. We develop chemical tools that dynamically report on Trx and GSH system activity in living cells. Multicolour activity probe panels can resolve context-dependent differences in redox activity as ratiometric “redox rainbow” signatures. Adapted probes can release therapeutics instead of reporters to selectively address redox-dysregulated tissues with redox prodrugs.