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<p>Chimeric Antigen Receptor (CAR) T cells are among the most promising cancer therapeutics of the past decade. However, immunogenic components, often of murine origin, can elicit anti-CAR immune responses that limit their persistence and efficacy. “Humanization” replaces murine sequences with human counterparts, reducing immunogenicity while preserving function. This article discusses mechanisms of CAR T cell rejection and the clinical potential of humanized CAR designs.</p>

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Humanisierung steigert die Wirksamkeit von CAR-T-Zelltherapien

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月1日

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  • Tobias D. Deller,
  • Toni Cathomen

摘要

Chimeric Antigen Receptor (CAR) T cells are among the most promising cancer therapeutics of the past decade. However, immunogenic components, often of murine origin, can elicit anti-CAR immune responses that limit their persistence and efficacy. “Humanization” replaces murine sequences with human counterparts, reducing immunogenicity while preserving function. This article discusses mechanisms of CAR T cell rejection and the clinical potential of humanized CAR designs.