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<p>Poxviruses transcribe their genes in temporal order in the host cell cytoplasm, almost entirely by self-encoded factors. These events are mainly studied in <i>Vaccinia</i>, a relatively harmless poxvirus with strong similarity to pathogenic subtypes. Poxviral transcription is catalyzed by a multi-subunit viral RNA polymerase, recruited to each promoter type by viral transcription factors. Cryo-EM analyses of initiation complexes revealed unique mechanisms and also analogies to eukaryotic transcription.</p>

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Do it yourself: Wie Pockenviren ihr Genom transkribieren

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月1日

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  • Stefan Jungwirth,
  • Clemens Grimm,
  • Utz Fischer

摘要

Poxviruses transcribe their genes in temporal order in the host cell cytoplasm, almost entirely by self-encoded factors. These events are mainly studied in Vaccinia, a relatively harmless poxvirus with strong similarity to pathogenic subtypes. Poxviral transcription is catalyzed by a multi-subunit viral RNA polymerase, recruited to each promoter type by viral transcription factors. Cryo-EM analyses of initiation complexes revealed unique mechanisms and also analogies to eukaryotic transcription.