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<p><i>Bartonella bacilliformis</i> is the etiological agent of the biphasic Carrión’s disease, endemic to the Andean highlands of South America. Infections with this human-pathogenic bacterium cause Oroya fever (acute phase) characterized by a severe hemolytic anemia with mortality rates reaching up to 88 % often followed by angioproliferative skin lesions (verruga peruana; chronic phase). Despite its medical importance, infection biology of <i>B. bacilliformis</i> and virulence determinants are largely unknown. Rising ciprofloxacin resistance and the climate-driven expansion of vector habitats underscore the urgent need for novel therapeutic approaches.</p>

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Die tödliche Gefahr aus den peruanischen Anden

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年3月1日

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  • Alexander A. Dichter,
  • Maximilian Schultheis,
  • Wibke Ballhorn,
  • Volkhard A. J. Kempf

摘要

Bartonella bacilliformis is the etiological agent of the biphasic Carrión’s disease, endemic to the Andean highlands of South America. Infections with this human-pathogenic bacterium cause Oroya fever (acute phase) characterized by a severe hemolytic anemia with mortality rates reaching up to 88 % often followed by angioproliferative skin lesions (verruga peruana; chronic phase). Despite its medical importance, infection biology of B. bacilliformis and virulence determinants are largely unknown. Rising ciprofloxacin resistance and the climate-driven expansion of vector habitats underscore the urgent need for novel therapeutic approaches.