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<p>Primary cilia are cellular antennae present on most human cells. Defects in primary cilia signaling or structure cause ciliopathies affecting nearly all organs. Cilia detect stimuli via surface receptors and convert them mainly through cAMP-dependent signaling into cellular responses, mainly through cAMP-dependent signaling. Opto- and chemogenetics, together with genetically endcoded biosensors, enable precise modulation and analysis of ciliary cAMP pathways, opening new therapeutic strategies.</p>

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Zilien als zelluläre Antennen

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年3月1日

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  • Jan N. Hansen,
  • Dagmar Wachten

摘要

Primary cilia are cellular antennae present on most human cells. Defects in primary cilia signaling or structure cause ciliopathies affecting nearly all organs. Cilia detect stimuli via surface receptors and convert them mainly through cAMP-dependent signaling into cellular responses, mainly through cAMP-dependent signaling. Opto- and chemogenetics, together with genetically endcoded biosensors, enable precise modulation and analysis of ciliary cAMP pathways, opening new therapeutic strategies.