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<p>Chinese Hamster Ovary cells (CHO) are the main production cell line for industrial manufacturing of biotherapeutics. The recent emergence of a reference genome and other genome-scale data for this cell line has generated a boost in our understanding of the mechanisms CHO cells use for efficient production and has also spotlighted the limitations for increased productivity. A recent genome wide deletion screen indicates that regions of the genome that have no known function may still be essential as their removal from the genome will instantly kill cells.</p>

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Genome-Scale Big Data boostet die Produktion von Biotherapeutika

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2026年2月25日

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  • Nicole Borth

摘要

Chinese Hamster Ovary cells (CHO) are the main production cell line for industrial manufacturing of biotherapeutics. The recent emergence of a reference genome and other genome-scale data for this cell line has generated a boost in our understanding of the mechanisms CHO cells use for efficient production and has also spotlighted the limitations for increased productivity. A recent genome wide deletion screen indicates that regions of the genome that have no known function may still be essential as their removal from the genome will instantly kill cells.