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<p>Activating genes in their endogenous genomic context is essential for studying gene regulation and cell identity, but was long technically limited. CRISPR-based gene activation (CRISPRa) enables programmable transcriptional control at native loci. DNA-free CRISPRa ribonucleo-proteins (dRNPs) allow transient, multiplexed gene activation without genomic modification and enable controlled modulation of cellular states, with potential relevance for future translational applications.</p>

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Gene anschalten statt umbauen: CRISPR aktiviert Zellprogramme ohne DNA-Eingriff

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月25日

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  • Tobias Schmidt,
  • Chandni Natalia Kumar,
  • Stefan H. Stricker

摘要

Activating genes in their endogenous genomic context is essential for studying gene regulation and cell identity, but was long technically limited. CRISPR-based gene activation (CRISPRa) enables programmable transcriptional control at native loci. DNA-free CRISPRa ribonucleo-proteins (dRNPs) allow transient, multiplexed gene activation without genomic modification and enable controlled modulation of cellular states, with potential relevance for future translational applications.