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<p><i>Aspergillus fumigatus</i> is a human pathogenic fungus capable of causing life-threatening, invasive infections. The rise in antimycotic resistance creates an urgent need for new therapeutic approaches. Using the clinically applied antimycotics 5-fluorocytosine, itraconazole and amphotericin B as examples, we describe how proteomics can provide detailed insights into antifungal modes of action, induced resistance pathways, and cellular stress responses.</p>

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Aufklärung pilzlicher Antimykotika-Resistenzmechanismen durch Proteomics

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2026年2月25日

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  • Thomas Krüger,
  • Olaf Kniemeyer,
  • Axel A. Brakhage

摘要

Aspergillus fumigatus is a human pathogenic fungus capable of causing life-threatening, invasive infections. The rise in antimycotic resistance creates an urgent need for new therapeutic approaches. Using the clinically applied antimycotics 5-fluorocytosine, itraconazole and amphotericin B as examples, we describe how proteomics can provide detailed insights into antifungal modes of action, induced resistance pathways, and cellular stress responses.