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<p>3D bioprinting enables the creation of human organ models with high physiological relevance. We present a perfusable liver model fabricated via sacrificial-free direct ink writing (SF-DIW), allowing one-step printing of hollow vascular networks without fugitive materials. After endothelialization and connection to a perfusion system, the model maintained high viability and supported cancer drug testing, offering a human-relevant alternative to animal studies.</p>

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3D-Biodruck perfundierbarer Krebsmodelle

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年11月22日

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  • Dongwei Wu,
  • Jens Kurreck

摘要

3D bioprinting enables the creation of human organ models with high physiological relevance. We present a perfusable liver model fabricated via sacrificial-free direct ink writing (SF-DIW), allowing one-step printing of hollow vascular networks without fugitive materials. After endothelialization and connection to a perfusion system, the model maintained high viability and supported cancer drug testing, offering a human-relevant alternative to animal studies.