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<p>Mechanosensation plays a key role in many physiological processes. Despite its importance, high-content methods for studying mechanosignaling at the cell level remain challenging. This article presents an approach to assess mechanosignaling in adherent cells using isotropic mechanical stretch combined with real-time Ca<sup>2+</sup> fluorescence imaging. This method integrates our <i>IsoStretcher</i> platform with image registration, cell segmentation, and single-cell and population-based Ca<sup>2+</sup> signaling analysis.</p>

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Mehr Content! Eine neue Biomechatronik-Lösung für die Mechanobiologie

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月8日

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  • Fabian Linsenmeier,
  • Sebastian Schürmann,
  • Oliver Friedrich

摘要

Mechanosensation plays a key role in many physiological processes. Despite its importance, high-content methods for studying mechanosignaling at the cell level remain challenging. This article presents an approach to assess mechanosignaling in adherent cells using isotropic mechanical stretch combined with real-time Ca2+ fluorescence imaging. This method integrates our IsoStretcher platform with image registration, cell segmentation, and single-cell and population-based Ca2+ signaling analysis.