Scholarlink

<p>Transposable elements (TEs) are mobile DNA sequences that have shaped genomes throughout evolution. In <i>Drosophila melanogaster</i>, LTR elements, TEs that are related to retroviruses, such as the <i>copia</i> retrotransposon persist and some are actively expressed. Using cryo-ET, we visualized <i>copia</i> and discovered its association with nuclear pores, suggesting NPC-mediated translocation of entire virus-like particles. Our study demonstrates the power of cryo-ET for studying mobile genetic elements <i>in situ</i>.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Wie Kryo-ET die zelluläre Strukturbiologie von Retrotransposons aufklärt

  • 期刊论文

  • 发表日期：

    2025年10月8日

查看全文
  • Sven Klumpe,
  • Jürgen M. Plitzko

摘要

Transposable elements (TEs) are mobile DNA sequences that have shaped genomes throughout evolution. In Drosophila melanogaster, LTR elements, TEs that are related to retroviruses, such as the copia retrotransposon persist and some are actively expressed. Using cryo-ET, we visualized copia and discovered its association with nuclear pores, suggesting NPC-mediated translocation of entire virus-like particles. Our study demonstrates the power of cryo-ET for studying mobile genetic elements in situ.