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<p>Living inside host cells provides significant advantages for human parasites like <i>Plasmodium</i> and <i>Leishmania</i>. Nevertheless, to complete their life cycle, they must eventually exit the host cell – a critical step that represents an attractive target for drug development. However, achieving the necessary combination of high spatial and temporal resolution imaging to capture egress dynamics remains a challenge and software pipelines for data analysis need to be advanced. Addressing these challenges will be key to unlocking the exit strategies of parasites.</p>

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EXIT-Strategien intrazellulärer Parasiten im Visier hochauflösender Bildgebung

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年10月8日

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  • Gabriele Pradel,
  • Friedrich Frischknecht

摘要

Living inside host cells provides significant advantages for human parasites like Plasmodium and Leishmania. Nevertheless, to complete their life cycle, they must eventually exit the host cell – a critical step that represents an attractive target for drug development. However, achieving the necessary combination of high spatial and temporal resolution imaging to capture egress dynamics remains a challenge and software pipelines for data analysis need to be advanced. Addressing these challenges will be key to unlocking the exit strategies of parasites.