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<p>Macrophages utilise the acidification of their luminal pH to inhibit the proliferation of pathogens. pH-sensitive fluorophores such as pHrodo Red enable real-time monitoring of this phagosomal acidification. Following endosomal uptake of pHrodo Red beads by macrophages, the low phagosomal pH results in a measurable increase in fluorescence intensity. Compared to conventional techniques this method offers a fast and automated way of analysing fluorescence intensity that can save time and money.</p>

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Untersuchungen zur Phagosomenreifung am Mikroplattenreader

  • 期刊论文

  • 发表日期：

    2025年6月18日

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  • Martin Mangold

摘要

Macrophages utilise the acidification of their luminal pH to inhibit the proliferation of pathogens. pH-sensitive fluorophores such as pHrodo Red enable real-time monitoring of this phagosomal acidification. Following endosomal uptake of pHrodo Red beads by macrophages, the low phagosomal pH results in a measurable increase in fluorescence intensity. Compared to conventional techniques this method offers a fast and automated way of analysing fluorescence intensity that can save time and money.