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<p>The genome and its regulatory elements undergo complex spatial and conformational changes during the establishment of cellular identity. Fluorescence in situ hybridization (FISH) probes the spatial organization of the genome at the single-cell level, but the detection of small genomic loci remains difficult. Here, we highlight recent developments in FISH methodologies that enable the detection of small genomic regions with improved sensitivity and specificity. With these advancements, researchers can now explore the spatial dynamics of regulatory elements in development and disease.</p>

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Die Vermessung des Genoms

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月18日

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  • Clemens Steinek,
  • Heinrich Leonhardt

摘要

The genome and its regulatory elements undergo complex spatial and conformational changes during the establishment of cellular identity. Fluorescence in situ hybridization (FISH) probes the spatial organization of the genome at the single-cell level, but the detection of small genomic loci remains difficult. Here, we highlight recent developments in FISH methodologies that enable the detection of small genomic regions with improved sensitivity and specificity. With these advancements, researchers can now explore the spatial dynamics of regulatory elements in development and disease.