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<p>Induced pluripotent stem cells (iPSCs) are created by reprogramming somatic cells using specific transcription factors. They resemble embryonic stem cells in their ability to self-renew and differentiate into all three germ layers. iPSCs are widely used for disease modeling due to their patient-specific genetic background. This article focuses on iPSC-based organoid and co-culture models to study the gut-brain axis, especially in the context of inflammatory and neurodegenerative diseases.</p>

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Induzierte pluripotente Stammzellen in der Erforschung der Darm-Hirn-Achse

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年6月18日

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  • Friederike Zunke,
  • Beate Winner,
  • Rocío López Posadas

摘要

Induced pluripotent stem cells (iPSCs) are created by reprogramming somatic cells using specific transcription factors. They resemble embryonic stem cells in their ability to self-renew and differentiate into all three germ layers. iPSCs are widely used for disease modeling due to their patient-specific genetic background. This article focuses on iPSC-based organoid and co-culture models to study the gut-brain axis, especially in the context of inflammatory and neurodegenerative diseases.