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<p>The immunoproteasome is a specific proteasome isoform constitutively expressed in hematopoetic cells and after interferon stimulation in none-immune cells. Its function has been predominantly correlated with antigen processing and MHC class I antigen presentation. However, in recent years it became increasingly clear that immunoproteasomes exert crucial functions in the maintenance of protein homeostasis under pro-inflammatory conditions.</p>

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Das Immunoproteasom: nicht nur eine Antigen-Prozessierungsmaschine

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年5月8日

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  • Peter Michael Kloetzel

摘要

The immunoproteasome is a specific proteasome isoform constitutively expressed in hematopoetic cells and after interferon stimulation in none-immune cells. Its function has been predominantly correlated with antigen processing and MHC class I antigen presentation. However, in recent years it became increasingly clear that immunoproteasomes exert crucial functions in the maintenance of protein homeostasis under pro-inflammatory conditions.