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<p>Targeted gene therapy faces the challenge of developing vectors that can specifically address certain cell populations. This study introduces DARPin-targeted AAV vectors (DART-AAVs) designed to target CD8positive T cells. DARPins, small binding proteins, were integrated into the capsid structure of AAV2 and AAV6. This modification enabled selective gene transfer without impairing efficiency, while the basic capsid structure remained unchanged.</p>

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DARPin-targetierte AAV-Vektoren für die T-Zell-spezifische Gentherapie

  • 期刊论文

  • 发表日期：

    2025年5月8日

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  • Luca Zinser

摘要

Targeted gene therapy faces the challenge of developing vectors that can specifically address certain cell populations. This study introduces DARPin-targeted AAV vectors (DART-AAVs) designed to target CD8positive T cells. DARPins, small binding proteins, were integrated into the capsid structure of AAV2 and AAV6. This modification enabled selective gene transfer without impairing efficiency, while the basic capsid structure remained unchanged.