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<p>DNA methylation is essential for cell identity and integrity. The genome of the mammalian germline undergoes two waves of genome-wide methylation reprogramming during embryonic development. Recent data revealed that the male germline in the adult is also continuously reprogrammed at each spermatogenic cycle, revealing windows of opportunity for lifelong impact on the paternal epigenome, potentially affecting fertility and the integrity of paternal non-genetic information.</p>

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Programmierung der DNA-Methylierungsmuster in der männlichen Keimbahn

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月25日

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  • Sandra Laurentino,
  • Nina Neuhaus

摘要

DNA methylation is essential for cell identity and integrity. The genome of the mammalian germline undergoes two waves of genome-wide methylation reprogramming during embryonic development. Recent data revealed that the male germline in the adult is also continuously reprogrammed at each spermatogenic cycle, revealing windows of opportunity for lifelong impact on the paternal epigenome, potentially affecting fertility and the integrity of paternal non-genetic information.