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<p>Organoids are powerful organ models for studying tissue development and disease, yet their structural and functional complexity remains limited due to the lack of controlled biochemical signaling. Our work introduces DNA-based microbeads that enable precise spatial and temporal release of signaling molecules within organoids, creating more realistic tissue structures. This versatile platform enhances the physiological potential of organoids, paving the way to advanced tissue models and therapeutic applications.</p>

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DNA-basierte Mikrokugeln als innovative Steuerungstechnologie für Organoide

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月25日

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  • Cassian Afting,
  • Tobias Walther,
  • Joachim Wittbrodt,
  • Kerstin Göpfrich

摘要

Organoids are powerful organ models for studying tissue development and disease, yet their structural and functional complexity remains limited due to the lack of controlled biochemical signaling. Our work introduces DNA-based microbeads that enable precise spatial and temporal release of signaling molecules within organoids, creating more realistic tissue structures. This versatile platform enhances the physiological potential of organoids, paving the way to advanced tissue models and therapeutic applications.