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<p>Pre-mRNA splicing of intron-containing transcripts is a prerequisite to yield functional mRNAs. Its regulation results in mRNA sequence or amount variations. How splicing shapes gene expression and physiology in microorganisms is not well understood beyond the common model budding yeast. This is also true for <i>Candida albicans</i>, one of the most prevalent human fungal pathogens. Recent studies highlight the impact of RNA processing on its virulence, providing insights into potential drug targets.</p>

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Prä-mRNA-Spleißen beeinflusst die Hyphenbildung bei Candida albicans

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年3月25日

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  • Livia Kupczok,
  • Pia Sternisek,
  • Oliver Bader,
  • Lydia Herzel

摘要

Pre-mRNA splicing of intron-containing transcripts is a prerequisite to yield functional mRNAs. Its regulation results in mRNA sequence or amount variations. How splicing shapes gene expression and physiology in microorganisms is not well understood beyond the common model budding yeast. This is also true for Candida albicans, one of the most prevalent human fungal pathogens. Recent studies highlight the impact of RNA processing on its virulence, providing insights into potential drug targets.