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<p>The genome of eukaryotes encodes thousands of proteins needed to ensure cell health. Hence, an imbalance in the genome has profound consequences for protein homeostasis (proteostasis). The genome and proteome are interlocked in a mutual relationship, which impacts the functions of cellular organelles like mitochondria. However, the underlying mechanisms remain an enigma. Here, we highlight this relationship and outline some open questions to be addressed.</p>

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How do genome abnormalities impact mitochondrial homeostasis?

  • 期刊论文

  • 出版模式：

    开放获取

  • 发表日期：

    2025年2月21日

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  • Olha Kurpa,
  • Prince Saforo Amponsah

摘要

The genome of eukaryotes encodes thousands of proteins needed to ensure cell health. Hence, an imbalance in the genome has profound consequences for protein homeostasis (proteostasis). The genome and proteome are interlocked in a mutual relationship, which impacts the functions of cellular organelles like mitochondria. However, the underlying mechanisms remain an enigma. Here, we highlight this relationship and outline some open questions to be addressed.