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<p>Iron-sulfur (FeS) clusters require a complex biosynthesis pathway, despite the simplicity of these versatile, inorganic protein cofactors. The process starts in mitochondria by action of the iron-sulfur cluster assembly (ISC) machinery and is the essential and minimal function of these organelles. The ISC system further assists the cytosolic iron-sulfur protein assembly (CIA) system in maturing FeS proteins in both cytosol and nucleus. Here, I briefly summarize our current mechanistic knowledge of this essential process of life.</p>

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Mitochondriale und zytosolische Systeme der Eisen-Schwefel-Proteinbiogenese

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  • 发表日期：

    2025年2月21日

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  • Roland Lill

摘要

Iron-sulfur (FeS) clusters require a complex biosynthesis pathway, despite the simplicity of these versatile, inorganic protein cofactors. The process starts in mitochondria by action of the iron-sulfur cluster assembly (ISC) machinery and is the essential and minimal function of these organelles. The ISC system further assists the cytosolic iron-sulfur protein assembly (CIA) system in maturing FeS proteins in both cytosol and nucleus. Here, I briefly summarize our current mechanistic knowledge of this essential process of life.