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<p>This study aimed to explore the association between serum ferritin and glutathione peroxidase 4 (Gpx4), markers of ferroptosis, with the severity of coronary artery stenosis and the occurrence of in-stent restenosis after percutaneous coronary intervention (PCI) in coronary artery disease (CAD) patients. The study encompassed 396 eligible CAD patients who underwent PCI, followed up for one year. A control group of 100 individuals was selected, matching the baseline data of CAD patients. Compared to healthy controls (HC), CAD patients showed a significant decrease in serum Gpx4 levels and an increase in ferritin levels. Significant disparities were observed in low-density lipoprotein cholesterol, Gensini score, serum Gpx4, and ferritin between the restenosis and no-restenosis groups (<i>p</i> &lt; 0.001). Serum levels of ferritin and Gpx4, markers associated with ferroptosis, correlate with the severity of coronary artery stenosis in CAD patients and the occurrence of in-stent restenosis after PCI.</p> Graphical Abstract <p></p>

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Ferroptosis Related Serum Gpx4 Correlates to Severity of Coronary Artery Stenosis, and in-Stent Restenosis in Patients

  • 期刊论文

  • 发表日期：

    2025年7月7日

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  • Xiufang Jiang,
  • Yanling Lei,
  • Yajuan Yin,
  • Fangfang Ma,
  • Gang Liu,
  • Mingqi Zheng

摘要

This study aimed to explore the association between serum ferritin and glutathione peroxidase 4 (Gpx4), markers of ferroptosis, with the severity of coronary artery stenosis and the occurrence of in-stent restenosis after percutaneous coronary intervention (PCI) in coronary artery disease (CAD) patients. The study encompassed 396 eligible CAD patients who underwent PCI, followed up for one year. A control group of 100 individuals was selected, matching the baseline data of CAD patients. Compared to healthy controls (HC), CAD patients showed a significant decrease in serum Gpx4 levels and an increase in ferritin levels. Significant disparities were observed in low-density lipoprotein cholesterol, Gensini score, serum Gpx4, and ferritin between the restenosis and no-restenosis groups (p < 0.001). Serum levels of ferritin and Gpx4, markers associated with ferroptosis, correlate with the severity of coronary artery stenosis in CAD patients and the occurrence of in-stent restenosis after PCI.

Graphical Abstract