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<p>Hypertrophic cardiomyopathy (HCM) is one of the most prevalent hereditary cardiovascular diseases.&#xa0;Eicosanoids are known to play a significant role in cardiovascular diseases and serve as biomarkers. In this study, plasma eicosanoids were profiled by LC–MS&#xa0;in a cohort of 78 healthy individuals and 73 patients diagnosed with HCM. Our findings reveal&#xa0;HCM patients exhibit downregulation of various eicosanoids, including AA, 5,6-DHET, 12-HETE, LXA4, EPA, etc. Notably, the combined predictive model incorporating 12-HETE and EPA demonstrates significant diagnostic value for HCM. Additionally, ten closely related metabolites showed significant positive correlations within the metabolic network graph. Eicosanoids such as 17,18-EEQ, LXA4, and 13-oxo-ODE exhibit significant negative correlations with plasma concentrations of hs-CRP and NT-proBNP in patients.&#xa0;Alterations in eicosanoid metabolism may be implicated in the pathophysiological processes underlying HCM.</p> Graphical Abstract <p></p>

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The Diagnostic Significance of Circulating Eicosanoid in Patients with Hypertrophic Cardiomyopathy

  • 期刊论文

  • 发表日期：

    2025年7月21日

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  • Yue Zhang,
  • Xinyu Liu,
  • Zhongze Zhang,
  • Weiyan Sun,
  • Wenjing Yue,
  • Le Liu,
  • Yi Zhu,
  • Xu Zhang,
  • Hong Wang

摘要

Hypertrophic cardiomyopathy (HCM) is one of the most prevalent hereditary cardiovascular diseases. Eicosanoids are known to play a significant role in cardiovascular diseases and serve as biomarkers. In this study, plasma eicosanoids were profiled by LC–MS in a cohort of 78 healthy individuals and 73 patients diagnosed with HCM. Our findings reveal HCM patients exhibit downregulation of various eicosanoids, including AA, 5,6-DHET, 12-HETE, LXA4, EPA, etc. Notably, the combined predictive model incorporating 12-HETE and EPA demonstrates significant diagnostic value for HCM. Additionally, ten closely related metabolites showed significant positive correlations within the metabolic network graph. Eicosanoids such as 17,18-EEQ, LXA4, and 13-oxo-ODE exhibit significant negative correlations with plasma concentrations of hs-CRP and NT-proBNP in patients. Alterations in eicosanoid metabolism may be implicated in the pathophysiological processes underlying HCM.

Graphical Abstract