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<p>The prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in relation to albumin levels for acute ischemic stroke (AIS) remains unclear. This study examined the correlation between inflammatory markers and nutritional status to predict 90-day outcomes in patients with AIS. A total of 5855 patients with acute cerebral infarction admitted to the Stroke Center at Jiangsu Province Hospital of Chinese Medicine between June 2017 and September 2023 were retrospectively analyzed. The NLR, SIRI, SII, and NLR-ALb were calculated using peripheral venous blood indicators obtained 24&#xa0;h post-admission. All patients were followed up 90&#xa0;days after discharge, and their prognosis was evaluated using the modified Rankin Scale (mRS). Logistic regression analysis, receiver operating characteristics, and Kaplan–Meier survival curves were used to explore the association between inflammatory markers and 90-day outcomes in patients with AIS. In conclusion, higher levels of NLR, SIRI, SII, and the NLR-ALB ratio are associated with poor outcomes following AIS.</p> Graphical Abstract <p></p>

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Correlation Between NLR to Albumin Ratio and 90-day Prognosis After Treatment for Acute Ischemic Stroke

  • 期刊论文

  • 发表日期：

    2025年6月24日

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  • Peian Liu,
  • Lianhong Ji,
  • Jiale Gan,
  • Xinyi Yang,
  • Yongxing Deng,
  • Junqi Liao,
  • Peiyi Mo,
  • Qing Zhu,
  • Hui Jiang,
  • Yunfei Han,
  • Zhaoyao Chen,
  • Wenlei Li,
  • Minghua Wu,
  • Yuan Zhu

摘要

The prognostic significance of the neutrophil-to-lymphocyte ratio (NLR) in relation to albumin levels for acute ischemic stroke (AIS) remains unclear. This study examined the correlation between inflammatory markers and nutritional status to predict 90-day outcomes in patients with AIS. A total of 5855 patients with acute cerebral infarction admitted to the Stroke Center at Jiangsu Province Hospital of Chinese Medicine between June 2017 and September 2023 were retrospectively analyzed. The NLR, SIRI, SII, and NLR-ALb were calculated using peripheral venous blood indicators obtained 24 h post-admission. All patients were followed up 90 days after discharge, and their prognosis was evaluated using the modified Rankin Scale (mRS). Logistic regression analysis, receiver operating characteristics, and Kaplan–Meier survival curves were used to explore the association between inflammatory markers and 90-day outcomes in patients with AIS. In conclusion, higher levels of NLR, SIRI, SII, and the NLR-ALB ratio are associated with poor outcomes following AIS.

Graphical Abstract