Shorter Leukocyte Telomere Length Is Associated with Increased Major Adverse Cardiovascular Events or Mortality in Patients with Essential Hypertension

期刊论文
发表日期：

2024年10月18日

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Hongna Fu,
Yuanting Zhu,
Luyang Lin,
Peng Jiang,
Guoyi Cai,
Lijin Zeng,
Xinyu Li,
Yuchun Zhang,
Chunhao Li,
Hong Zhan,
Bo Zhang,
Zhen Yang

摘要

The association between leukocyte telomere length (LTL) alteration and major adverse cardiovascular events (MACE) or mortality in patients with hypertension is still unclear. 20,034 patients with essential hypertension were enrolled from UK biobank. Multivariable COX regression models were performed to assess the association. LTL was shorter in hypertensive patients with MACE compared to those without MACE. Hypertensive patients in the lowest LTL quartile were at higher risk to develop MACE (adjusted HR 1.15 [95% CI 1.02–1.29], vs top LTL quartile, p-trend = 0.03). Similarly, shorter LTL was related with increased mortality (adjusted HR 1.18[95% CI 1.06–1.3], lowest vs top LTL quartile, p-trend < 0.001). This investigation demonstrated that shorter LTL is associated with increased risk of MACE or mortality in patients with essential hypertension, which indicates that LTL may be a potential predictor of prognosis or underlying therapeutic target for hypertension.

Graphical Abstract

This study demonstrated that shorter LTL is associated with increased risk of MACE or mortality in patients with essential hypertension