Scholarlink

<p>Retinal organoids (ROs) are three-dimensional <i>in vitro</i> models that replicate the specific cellular composition and inner structure of the retina. Currently, ROs derived from human pluripotent stem cells (hPSCs) have been shown to mimic both the structure and function of the human retina. Furthermore, ROs function as a powerful model system for researchers, facilitating the investigation of the pathogenesis and treatment strategies of retinal diseases. Despite their development for over a decade, ROs remain limited in terms of complexity and clinical application. This review summarizes recent advances in the development of retinal differentiation methods and underscores their potential applications in disease modeling, gene therapy, cell transplantation, and drug screening. In addition, it proposes research directions that are geared towards advancing RO methodologies to further broaden their applications.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Current Advances and Applications of Retinal Organoids

  • 期刊论文

  • 发表日期：

    2026年2月7日

查看全文
  • Dan-Ni Zhou,
  • Shu-Guang Yang,
  • Saijilafu,
  • Feng-Quan Zhou

摘要

Retinal organoids (ROs) are three-dimensional in vitro models that replicate the specific cellular composition and inner structure of the retina. Currently, ROs derived from human pluripotent stem cells (hPSCs) have been shown to mimic both the structure and function of the human retina. Furthermore, ROs function as a powerful model system for researchers, facilitating the investigation of the pathogenesis and treatment strategies of retinal diseases. Despite their development for over a decade, ROs remain limited in terms of complexity and clinical application. This review summarizes recent advances in the development of retinal differentiation methods and underscores their potential applications in disease modeling, gene therapy, cell transplantation, and drug screening. In addition, it proposes research directions that are geared towards advancing RO methodologies to further broaden their applications.