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<p>How do millisecond-scale neural activities mediate second-scale behaviors? We recorded brain-wide activity in mice performing an olfactory working-memory task to decipher the cross-region organization of activity. Spike-correlograms analysis revealed millisecond within- and cross-region spike couplings, which were enriched among memory-encoding neurons with similar odor preferences. Spike coupling linked neurons into motifs of chains, single loops, and nested loops, especially among hippocampal and prefrontal-cortex neurons. Spike-coupling direction and activity-chain propagation aligned with that of memory-associated activity waves. Intriguingly, activity motifs were replayed before and after task performance, and during inter-trial intervals. Motifs exhibited hierarchical organization, with progressively longer time constants and the number of participating neurons. Thus, hierarchically organized and replayed cross-region spiking motifs are modulated on demand during the delay period, providing a potential mechanism for perceptual working-memory maintenance.</p>

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Hierarchical Replay of Multi-regional Sequential Spiking Associated with Working Memory

  • 期刊论文

  • 出版模式：

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  • 发表日期：

    2025年10月31日

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  • Ermeng Huang,
  • Da Xu,
  • Huangao Zhu,
  • Zhaoqin Chen,
  • Yulei Chen,
  • Shujun Lei,
  • Jiawei Liu,
  • Chengyu T. Li,
  • Xiaoxing Zhang

摘要

How do millisecond-scale neural activities mediate second-scale behaviors? We recorded brain-wide activity in mice performing an olfactory working-memory task to decipher the cross-region organization of activity. Spike-correlograms analysis revealed millisecond within- and cross-region spike couplings, which were enriched among memory-encoding neurons with similar odor preferences. Spike coupling linked neurons into motifs of chains, single loops, and nested loops, especially among hippocampal and prefrontal-cortex neurons. Spike-coupling direction and activity-chain propagation aligned with that of memory-associated activity waves. Intriguingly, activity motifs were replayed before and after task performance, and during inter-trial intervals. Motifs exhibited hierarchical organization, with progressively longer time constants and the number of participating neurons. Thus, hierarchically organized and replayed cross-region spiking motifs are modulated on demand during the delay period, providing a potential mechanism for perceptual working-memory maintenance.