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<p>Clinical studies have suggested that increased plasma oxytocin (OT) levels are a promising biomarker for bipolar disorder (BD), and our earlier post-mortem study found increased OT activity in the hypothalamic paraventricular nucleus (OT<sup>PVN</sup>) in BD. However, the potential contribution of the supraoptic nucleus (SON, OT<sup>SON</sup>), a major part of the central OT system, to BD remains unknown. We therefore systematically performed independent acute or chronic chemogenetic activation of OT<sup>PVN</sup>, OT<sup>SON</sup>, or OT<sup>PVN+SON</sup> experiments in OT-cre mice. We found that acute activation of OT<sup>PVN+SON</sup> neurons led to slight mania-like (anti-depression-like) behaviors both in male and female mice, while chronic activation of OT<sup>PVN</sup> or OT<sup>PVN+SON</sup> led to sex-dependent behavioural changes from depression/anxiety-like to mania-like, accompanied by stress-related molecular changes in a sex- dependent manner in the medial prefrontal cortex. Our findings imply that OT may be involved in bipolar-like&#xa0;mood changes in a sex- and dosage-dependent manner.</p>

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Hypothalamic Oxytocin Neuronal Activation Induces Bipolar-Like Mood Changes in Mice in a Sex- and Dosage-Dependent Manner

  • 期刊论文

  • 发表日期：

    2025年8月22日

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  • Hong Tan,
  • Shizhen Jin,
  • Wenjin Lv,
  • Lingyu Guo,
  • Peiran Jiang,
  • Yongjian Li,
  • Mengjia Shi,
  • Danting Wang,
  • Yongcheng Wang,
  • Aimin Bao

摘要

Clinical studies have suggested that increased plasma oxytocin (OT) levels are a promising biomarker for bipolar disorder (BD), and our earlier post-mortem study found increased OT activity in the hypothalamic paraventricular nucleus (OTPVN) in BD. However, the potential contribution of the supraoptic nucleus (SON, OTSON), a major part of the central OT system, to BD remains unknown. We therefore systematically performed independent acute or chronic chemogenetic activation of OTPVN, OTSON, or OTPVN+SON experiments in OT-cre mice. We found that acute activation of OTPVN+SON neurons led to slight mania-like (anti-depression-like) behaviors both in male and female mice, while chronic activation of OTPVN or OTPVN+SON led to sex-dependent behavioural changes from depression/anxiety-like to mania-like, accompanied by stress-related molecular changes in a sex- dependent manner in the medial prefrontal cortex. Our findings imply that OT may be involved in bipolar-like mood changes in a sex- and dosage-dependent manner.