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Introduction <p>Major burn injuries are associated with profound hematological and immunological alterations that influence patient outcomes. Serial hematological parameters are routinely available in burn units and may provide useful prognostic information during the course of hospitalization. This study analysed hematological trends in pediatric and adult burn patients with major burns and evaluated their association with clinical outcomes.</p> Patients and Methods <p>A comparative analysis of historical patient records was performed at a tertiary burn centre between April 2023 and April 2025. A total of 128 patients with burns involving more than 20% total body surface area (TBSA) were included and divided into pediatric (&lt; 18&#xa0;years, n = 64) and adult (≥ 18&#xa0;years, n = 64) cohorts. Demographic details, burn characteristics, inhalational injury, serial hematological parameters including hemoglobin (HB), total leukocyte count (TLC), total platelet count (TPC), differential leukocyte counts and outcomes were analysed over a 29-day period.</p> Results <p>Scald injury predominated in pediatric patients, whereas thermal and electrical burns were more common in adults. Adult patients demonstrated significantly higher TBSA involvement, deeper burns and greater incidence of inhalational injury. Persistently lower HB, TLC and TPC values were associated with non-survival in both groups. Survivors demonstrated gradual hematological recovery during the late post-burn period, while non-survivors developed progressive leukopenia and thrombocytopenia. The divergence between survivor and non-survivor hematological curves became more apparent after the third post-burn week and was particularly pronounced among pediatric non-survivors.</p> Conclusion <p>Major burn injuries demonstrated distinct hematological response patterns in pediatric and adult patients. Persistently declining leukocyte and platelet counts were associated with poor outcomes in both age groups. Serial monitoring of routinely available hematological parameters may complement clinical assessment in patients with major burns.</p>

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Thrombocytopenia and Leukopenia in Burn Patients: A Comparative Study of Clinical Characteristics, Risk Factors and Prognostic Implications in Pediatric and Adult Populations

  • 期刊论文

  • 发表日期：

    2026年6月18日

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  • Syama Sundar Behera,
  • Sanjay Kumar Giri,
  • Vidush Kumar,
  • Anshuman Sarangi,
  • Ashok Kumar Sarangi

摘要

Introduction

Major burn injuries are associated with profound hematological and immunological alterations that influence patient outcomes. Serial hematological parameters are routinely available in burn units and may provide useful prognostic information during the course of hospitalization. This study analysed hematological trends in pediatric and adult burn patients with major burns and evaluated their association with clinical outcomes.

Patients and Methods

A comparative analysis of historical patient records was performed at a tertiary burn centre between April 2023 and April 2025. A total of 128 patients with burns involving more than 20% total body surface area (TBSA) were included and divided into pediatric (< 18 years, n = 64) and adult (≥ 18 years, n = 64) cohorts. Demographic details, burn characteristics, inhalational injury, serial hematological parameters including hemoglobin (HB), total leukocyte count (TLC), total platelet count (TPC), differential leukocyte counts and outcomes were analysed over a 29-day period.

Results

Scald injury predominated in pediatric patients, whereas thermal and electrical burns were more common in adults. Adult patients demonstrated significantly higher TBSA involvement, deeper burns and greater incidence of inhalational injury. Persistently lower HB, TLC and TPC values were associated with non-survival in both groups. Survivors demonstrated gradual hematological recovery during the late post-burn period, while non-survivors developed progressive leukopenia and thrombocytopenia. The divergence between survivor and non-survivor hematological curves became more apparent after the third post-burn week and was particularly pronounced among pediatric non-survivors.

Conclusion

Major burn injuries demonstrated distinct hematological response patterns in pediatric and adult patients. Persistently declining leukocyte and platelet counts were associated with poor outcomes in both age groups. Serial monitoring of routinely available hematological parameters may complement clinical assessment in patients with major burns.