Scholarlink

<p>Prevalence of Spontaneous Bacterial Peritonitis (SBP) among cirrhotic with ascites is 10%. Empirical antibiotics early in the course of illness improves survival. Rising drug resistance have rendered first line antimicrobials (3rd generation cephalosporin and quinolones) ineffective. We studied the resistance pattern in SBP patients and its impact on survival. Culture positive SBP patients were included in the study (Sep 2018 to Feb 2021). Organisms in ascitic fluid were identified by conventional biochemical tests and MALDI-ToF. Antibiotic sensitivity testing was done according to standard guidelines. Demographic and clinical profile were evaluated by appropriate statistical tests. Out of 1213 patients in whom diagnostic paracentesis was performed, 52 culture positive samples from cirrhotic SBP patients were analyzed. Most common organisms were <i>E. coli</i> (36.53%, <i>n</i> = 19) and <i>Pseudomonas aeruginosa</i> (23.07%, <i>n</i> = 8). All isolates of <i>E.coli</i> and <i>Klebsiella</i> were resistant to cephalosporins. A total of 22(42.31%) multi-drug resistant isolates were identified, 6(11.54%) out of which were extremely-drug resistant (XDR). High serum creatinine and presence of XDR isolates were independent predictors of mortality. Resistance among microorganisms is on a rise. First line drugs are usually ineffective. Odds of mortality rises five-fold in the presence of XDR infection. It is thus, important to develop local and regional antibiograms and modify treatment protocols.</p>

错误：搜索内容不能为空，请输入英文关键词
错误：关键词超出字数限制，请精简
高级检索

Resistant Bacterial Infection in Cirrhotic Patients with Spontaneous Bacterial Peritonitis: A Harbinger of Poor Outcome

  • 期刊论文

  • 发表日期：

    2025年11月26日

查看全文
  • Chinmoy Sahu,
  • Richa Sinha,
  • Ashima Jamwal,
  • Rahul,
  • Aakash Roy,
  • Prabhakar Mishra

摘要

Prevalence of Spontaneous Bacterial Peritonitis (SBP) among cirrhotic with ascites is 10%. Empirical antibiotics early in the course of illness improves survival. Rising drug resistance have rendered first line antimicrobials (3rd generation cephalosporin and quinolones) ineffective. We studied the resistance pattern in SBP patients and its impact on survival. Culture positive SBP patients were included in the study (Sep 2018 to Feb 2021). Organisms in ascitic fluid were identified by conventional biochemical tests and MALDI-ToF. Antibiotic sensitivity testing was done according to standard guidelines. Demographic and clinical profile were evaluated by appropriate statistical tests. Out of 1213 patients in whom diagnostic paracentesis was performed, 52 culture positive samples from cirrhotic SBP patients were analyzed. Most common organisms were E. coli (36.53%, n = 19) and Pseudomonas aeruginosa (23.07%, n = 8). All isolates of E.coli and Klebsiella were resistant to cephalosporins. A total of 22(42.31%) multi-drug resistant isolates were identified, 6(11.54%) out of which were extremely-drug resistant (XDR). High serum creatinine and presence of XDR isolates were independent predictors of mortality. Resistance among microorganisms is on a rise. First line drugs are usually ineffective. Odds of mortality rises five-fold in the presence of XDR infection. It is thus, important to develop local and regional antibiograms and modify treatment protocols.