<p>Regenerative medicine is an emerging field that focuses on repairing or replacing tissues and organs damaged by age, disease, trauma or congenital defects. It is well known that the main field of plastic surgery is tissue repair. The cellular therapies used today include platelet-rich plasma (PRP), platelet-rich fibrin (PRF), stem cells (autologous and allogeneic), stromal vascular fraction (SVF), adipose tissue transplantation, fibroblast cell culture and exosome therapies. Stem cells are cell types defined by their ability to renew themselves, proliferate indefinitely, differentiate into other cells and repair the damaged structure when injected into damaged tissue. Although SVF cannot be described as stem cells, we can define it as a cocktail containing mesenchymal stem cells, rich in growth factors, adipocyte progenitors, fibroblasts, endothelial progenitors, endothelial cells and predominantly stromal cells. Exosomes have many more advantages than the effects we can achieve with stem cells. Increasing angiogenesis, anti-inflammatory and immunomodulatory effects, providing tissue regeneration are important benefits. In regenerative medicine, cellular therapies are used in the treatment of many diseases, while in plastic surgery, it is widely used in wound, burn, scar, skin and hair treatment by exploiting its properties such as increasing angiogenesis, anti-inflammatory and immunomodulatory effects, and tissue regeneration.</p>

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Our Clinical Experience in Regenerative Medicine Applications and Cellular Therapies in Plastic Surgery

  • Fatma Bilgen Bekerecioğlu

摘要

Regenerative medicine is an emerging field that focuses on repairing or replacing tissues and organs damaged by age, disease, trauma or congenital defects. It is well known that the main field of plastic surgery is tissue repair. The cellular therapies used today include platelet-rich plasma (PRP), platelet-rich fibrin (PRF), stem cells (autologous and allogeneic), stromal vascular fraction (SVF), adipose tissue transplantation, fibroblast cell culture and exosome therapies. Stem cells are cell types defined by their ability to renew themselves, proliferate indefinitely, differentiate into other cells and repair the damaged structure when injected into damaged tissue. Although SVF cannot be described as stem cells, we can define it as a cocktail containing mesenchymal stem cells, rich in growth factors, adipocyte progenitors, fibroblasts, endothelial progenitors, endothelial cells and predominantly stromal cells. Exosomes have many more advantages than the effects we can achieve with stem cells. Increasing angiogenesis, anti-inflammatory and immunomodulatory effects, providing tissue regeneration are important benefits. In regenerative medicine, cellular therapies are used in the treatment of many diseases, while in plastic surgery, it is widely used in wound, burn, scar, skin and hair treatment by exploiting its properties such as increasing angiogenesis, anti-inflammatory and immunomodulatory effects, and tissue regeneration.