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<p>‘Cloud sign’ refers to the central hyper intensity with peripheral hypo-intense rim observed in the hepatobiliary phase of CE-MRI. Although more common in intrahepatic cholangiocarcinoma, it cannot exclude the diagnosis of hepatocellular carcinoma (HCC). Enhancement characteristics on other phases and ancillary imaging findings combined with specific tumour markers help differentiate the lesions with cloud sign. Here we report a case of well-differentiated HCC demonstrating ‘Cloud sign’.</p>

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Cloud Sign in Well-differentiated Hepatocellular Carcinoma

  • 期刊论文

  • 发表日期：

    2025年7月25日

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  • Komalavalli Subbiah,
  • Srinivasan Kalyanasundaram,
  • Dillibabu Ethiraj

摘要

‘Cloud sign’ refers to the central hyper intensity with peripheral hypo-intense rim observed in the hepatobiliary phase of CE-MRI. Although more common in intrahepatic cholangiocarcinoma, it cannot exclude the diagnosis of hepatocellular carcinoma (HCC). Enhancement characteristics on other phases and ancillary imaging findings combined with specific tumour markers help differentiate the lesions with cloud sign. Here we report a case of well-differentiated HCC demonstrating ‘Cloud sign’.