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<p>In tertiary cancer care in remote region, timely and accurate diagnosis of solid tumors is crucial for effective treatment and improved patient outcomes. Routine histopathological examination often entails delays, posing challenges for patients who cannot afford multiple visits to the hospital. A frozen section diagnosis offers a potential solution by providing rapid results, but its validity for initial diagnosis needs evaluation. This operational research aimed to assess the validity of the frozen section as compared to routine histopathological examination&#xa0;for initial diagnosis of solid tumors in a tertiary cancer centre in Assam, north-eastern India. In this cross-sectional study involving secondary data of 1035 specimen undergoing both the frozen section and histopathological examination between 2014 and 2022, 810 (78.3%) were confirmed as cancer on the histopathological examination. The primary cancer sites varied, with head and neck being the most common. Overall, the positive predictive value (PPV) was 95.5% and negative predictive value (NPV) was 55.6%. Across all examined categories, four groups, namely head and neck, colorectal, upper gastrointestinal, and female reproductive system, PPV ranged from 90.2 to 97.1% and NPV from 48.1 to 58.0%. In a tertiary cancer centre with a high burden of confirmed solid cancer among specimen examined, positive frozen section results have high utility. Incorporating the frozen section diagnosis into routine practice in similar settings has the potential to enhance the efficiency of cancer care delivery.</p>

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Upfront Frozen Section Histopathology in Solid Tumors in High Volume Centres as “Point of Care Test”

  • 期刊论文

  • 发表日期：

    2025年3月4日

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  • Ravi Kannan,
  • Kapil Malik,
  • Anuradha Talukdar,
  • Monoj Deka,
  • Shashidhar V. Karpurmath,
  • K. Niraimathi,
  • Hemant Deepak Shewade,
  • Ritesh Tapkire

摘要

In tertiary cancer care in remote region, timely and accurate diagnosis of solid tumors is crucial for effective treatment and improved patient outcomes. Routine histopathological examination often entails delays, posing challenges for patients who cannot afford multiple visits to the hospital. A frozen section diagnosis offers a potential solution by providing rapid results, but its validity for initial diagnosis needs evaluation. This operational research aimed to assess the validity of the frozen section as compared to routine histopathological examination for initial diagnosis of solid tumors in a tertiary cancer centre in Assam, north-eastern India. In this cross-sectional study involving secondary data of 1035 specimen undergoing both the frozen section and histopathological examination between 2014 and 2022, 810 (78.3%) were confirmed as cancer on the histopathological examination. The primary cancer sites varied, with head and neck being the most common. Overall, the positive predictive value (PPV) was 95.5% and negative predictive value (NPV) was 55.6%. Across all examined categories, four groups, namely head and neck, colorectal, upper gastrointestinal, and female reproductive system, PPV ranged from 90.2 to 97.1% and NPV from 48.1 to 58.0%. In a tertiary cancer centre with a high burden of confirmed solid cancer among specimen examined, positive frozen section results have high utility. Incorporating the frozen section diagnosis into routine practice in similar settings has the potential to enhance the efficiency of cancer care delivery.